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With the Bone Trial, researchers tried to figure out whether bone density increased after testosterone treatment in older men with low testosterone levels. They tested 28 men with low testosterone levels and 28 matched men in the study.Testosterone levels in older men can drop by 5% to 10%. It's likely that this drop will accelerate if testosterone levels get back to normal, because testosterone is an important natural hormone that is produced by the pituitary gland in the brain and plays a key role in regulating muscle growth and bone health. The researchers hypothesized that men with low testosterone levels might have an enlarged prostate gland at their base of the penis, and possibly a smaller prostate that would prevent the prostate from filling with fluid during ejaculation. They hypothesized that the enlarged prostate would have less sensitivity to the effects of testosterone than the normal prostate.They wanted to see whether they could measure blood levels of testosterone using blood samples, and testicular volume to determine whether there were any side effects. They tested 28 men, ages 47 to 56, with testosterone levels of 9 to 10 ng/mL and 26 healthy men with testosterone levels of 5 to 7 ng/mL. After a month of testosterone treatment, the men whose testosterone levels were higher in the testosterone group began having their testes shrink -- about 50% of the men in the testosterone group got rid of a half to two thirds of their prostate and about 40% of the other men in the testosterone group shrunk their testes."We knew this would increase bone density," Dr. Kowalewski says, "because our research had shown that testosterone was protective for men with high bone density."When they compared the men who got better bone density to those who didn't have better bone density at all, and compared the men who had better bone density to men with no improvements, the researchers identified four possible mechanisms that might be affecting testosterone in the older men. The researchers found that bone density in the lower half of the pelvis remained significantly lower in the testosterone group than in the controls, suggesting that a factor in the aging process is being increased in men taking testosterone."If testosterone helps to increase bone density, it's important to know whether that increased bone density continues over time because it seems to have a positive impact on prostate health as we age." says Dr. Kowalewski."We knew that low testosterone levels reduce prostate volume and blood flow, so it is plausible that lowering testosterone will improve prostate health," Dr. Kowalewski says. And as testosterone levels get back to normal, he will continue monitoring the effects of testosterone treatment on men with low testosterone to determine whetherRelated Article: